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Highly Cited Papers

Giaever G, Chu AM, Ni L, Connelly C, Riles L, Véronneau S, Dow S, Lucau-Danila A, Anderson K, André B, Arkin AP, Astromoff A, El Bakkoury M, Bangham R, Benito R, Brachat S, Campanaro S, Curtiss M, Davis K, Deutschbauer, Entian K-D, Flaherty P, Foury F, Garfinkel DJ, Gerstein M, Gotte D, Güldener U, Hegemann JH, Hempel S, Herman Z, Jaramillo DF, Kelly DE, Kelly SL, Kötter P, LaBonte D, Lamb DC, Lan N, Liang H, Liao H, Liu L, Luo C, Lussier M, Mao R, Menard P, Ooi SL, Revuelta JL, Roberts CJ, Rose M, Ross-Macdonald P, Scherens B, Schimmack G, Shafer B, Shoemaker DD, Sookhai-Mahadeo S, Storms RK, Strathern JN, Valle G, Voet M, Volckaert G, Wang C-Y, Ward TR, Wilhelmy J, Winzeler EA, Yang Y, Yen G, Youngman E, Yu K, Bussey H, Boeke JD, Snyder M, Philippsen P, Davis RW, Johnston M. Functional profiling of the Saccharomyces cerevisiae genome. Nature. 2002, 418(6896), 387-391.

  • 3624 citations
  • The UK laboratory in the transatlantic yeast gene deletion project

Denning DW, Venkareswarlu K, Oakley KL, Anderson MJ, Manning NJ, Kelly SL. Itraconazole resistance in Aspergillus fumigatus. Antimicrobial Agents and Chemotherapy. 1997, 41(6), 1364-1368.

  • 463 citations

Lupetti A, Danesi R, Campa M, Del Tacca, M, Kelly S. Molecular basis of resistance to azole antifungals, Trends in Molecular Medicine. 2002, 8(2), 76-81.

  • 407 citations

Franz R, Kelly SL, Lamb DC, Kelly DE, Ruhnke M, Morschhäuser J. Multiple molecular mechanisms contribute to a stepwise development of fluconazole resistance in clinical Candida albicans. Antimicrobial Agents and Chemotherapy. 1998, 42(12), 3065-3072.

  • 335 citations

Kelly SL, Lamb DC, Kelly DE, Manning NJ, Loeffler J, Hebart H, Schumaker U, Einsele H. Resistance to fluconazole and cross resistance to amphotericin B in Candida albicans from AIDS patients caused by defective sterol delta 5,6-desaturation. FEBS Letters. 1997, 400(1), 80-82.

  • 312 citations

Kelly SLLamb DC, Corran AJ, Baldwin BC, Kelly DE. Mode of action and resistance to azole antifungals associated with the formation of 14 alpha-methylergosta-8,24(28)-dien-3 beta, 6 alpha-diol. Biochemical and Biophysical Research Communications. 1995, 207(3), 910-915.

  • 216 citations

Lamb DC, Kelly DE, Schunck WH, Shyadehi AZ, Akhtar M, Lowe DJ, Baldwin BC, Kelly SL. The mutation T315A in Candida albicans sterol 14 alpha-demethylase causes reduced enzyme activity and fluconazole resistance through reduced affinity. Journal of Biological Chemistry. 1997, 272(9), 5682-5688.

  • 210 citations

Watson PF, Rose ME, Ellis SW, England H, Kelly SL. Defective sterol C5,6 desaturation and azole resistance: a new hypothesis for the mode of action of azole antifungals. Biochemical and Biophysical Research Communications. 1989, 164(3), 1170-1175.

  • 177 citations

Löffler J, Kelly SL, Hebart H, Schumacher U, Lass-Flörl C, Einsele H. Molecular analysis of cyp51 from fluconazole resistant Candida albicans strains. FEMS Microbiology Letters. 1997, 151(2), 263-268.

  • 165 citations

Kelly SL, Lamb DC, Kelly DE, Loeffler J, Einsele H. Resistance to fluconazole and amphotericin in Candida albicans from AIDS patients. The Lancet. 1996, 348(9040), 1523-1524.

  • 153 citations

Daum G, Tuller G, Nemec T, Hrastnik C, Balliano G, Cattel L, Milla P, Rocco F, Conzelmann A, Vionnet C, Kelly DE, Kelly S, Schweizer E, Schüller HJ, Hojad U, Greiner E, Finger K. Systematic analysis of yeast strains with possible defects in lipid metabolism. Yeast. 1999, 15(7), 601-614.

  • 147 citations

Lamb DCKelly DE, White TC, Kelly SL. The R467K amino acid substitution in Candida albicans sterol 14 alpha-demethylase causes drug resistance through reduced affinity. Antimicrobial Agents and Chemotherapy. 2000, 44(1), 63-67.

  • 137 citations

Zhao B, Guengerich FP, Bellamine, A, Lamb DC, Izumikawa M, Lei L, Podust LM, Sundaramoorthy M, Kalaitzis JA, Reddy LM, Kelly SL, Moore BS, Stec D, Voehler M, Falck JR, Shimada T, Waterman MR. Binding of two flaviolin substrate molecules, oxidative coupling, and crystal structure of Streptomyces coelicolor A3(2) cytochrome P450 158A2. Journal of Biological Chemistry. 2005, 280(12), 11599-11607.

  • 133 citations

Lamb DC, Skaug T, Song HL, Jackson CJ, Podust LM, Waterman MR, Kell DB, Kelly DE, Kelly SL. The cytochrome P450 complement (CYPome) of Streptomyces coelicolor A3(2). Journal of Biological Chemistry. 2002, 277(27), 24000-24005.

  • 132 citations

Shyadehi AZ, Lamb DCKelly SLKelly DE, Schunck WH, Wright JN, Corina D, Akhtar M. The mechanism of the acyl-carbon bond cleavage reaction catalyzed by recombinant sterol 14 alpha-demethylase (other names are lanosterol 14 alpha-demethylase, P-450DM and CYP51). Journal of Biological Chemistry. 1996, 271(21), 12445-12450.

  • 131 citations

Jackson CJ, Barton RC, Kelly SL, Evans EGV. Strain identification of Trichophyton rubrum by specific amplication of subrepeat elements in the ribosomal DNA nontranscribed spacer. Journal of Clinical Microbiology. 2000, 38(12), 4527-4534.

  • 127 citations

Kelly SL, Lamb DC, Baldwin BC, Corran AJ, Kelly DE. Characterisation of Saccharomyces cerevisiae CYP61, sterol delta 22-desaturase, and inhibtion by azole antifungal agents. Journal of Biological Chemistry. 1997, 272(15), 9986-9988.

  • 126 citations

Zhao B, Lin X, Lei L, Lamb DCKelly SL, Waterman MR, Cane DE. Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor A3(2). Journal of Biological Chemistry. 2008, 283(13), 8183-8189. 

  • 117 citations

Kelly SL, Lamb DC, Taylor M, Corran AJ, Baldwin BC, Powderly WG. Resistance to amphotericin B associated with defective sterol Δ8→7 isomerase in a Cryptococcus neoformans strain from an AIDS patient. FEMS Microbiology Letters. 1994. 122(1-2), 39-42.

  • 112 citations

Kelly SL, Lamb DC, Kelly DE. Y132H substitution in Candida albicans sterol 14alpha-demethylase confers fluconazole resistance by preventing binding to haem. FEMS Microbiology Letters. 1999. 180, 171-175.

  • 107 citations

Lamb DC, Waterman MR, Kelly SL, Guengerich FP. Cytochromes P450 and drug discovery. Current Opinion in Biotechnology. 2007. 18(6), 504-512.

  • 106 citations

Akhtar MK, Kelly SL, Kaderbhai MA. Cytochrome b5 modulation of 17α hydroxylase and 17-20 lyase (CYP17) activities in steroidgenesis. Journal of Endocrinology. 1999. 180(2), 171-175.

  • 102 citations

Kelly SL, Lamb DC, Loeffler J, Einsele H, Kelly DE. The G464S amino acid substitution in Candida albicans sterol 14alpha-demethylase causes fluconazole resistance in clinic through reduced affinity. Biochemical and Biophysical Research Communications. 1999. 262(1), 174-179.

  • 102 citations

Martel CM, Parker JE, Bader O, Weig M, Gross U, Warrilow AGS, Rolley N, Kelly DE, Kelly SL. Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. Antimicrobial Agents and Chemotherapy. 2010. 54(11), 4527-4533.

  • 101 citations

Kelly SL, Kelly DE. Microbial cytochromes P450: biodiversity and biotechnology. Where do cytochromes P450 come from, what do they do and what can they do for us? Phil Trans R Soc B. 2013. 368(1612), 20120476.
  • 100 citations

Lamb DC, Lei L, Warrilow AG, Lepesheva GI, Mullins JG, Waterman MR, Kelly SL. The first virally encoded cytochrome P450. Journal of Virology. 2009. 83(16), 8266-8269.

  • 95 citations

Masaphy S, Levanon D, Henis Y, Venkateswarlu K, Kelly SL. Evidence for cytochrome P-450 and P-450-mediated benzo(a)pyrene hydroxylation in the white rot fungus Phanerochaete chrysosporiumFEMs Microbiology Letters. 1996. 135(1), 51-55.

  • 94 citations

Lamb DC, Ikeda H, Nelson DR, Ishikawa J, Skaug T, Jackson C, Omura S, Waterman MR, Kelly SL. Cytochrome P450 complement (CYPome) of the avermectin-producer Streptomyces avermitilis and comparison to that of Streptomyces coelicolor A3(2). Biochemical and Biophysical Research Communications. 2003. 307(3), 610-619.

  • 92 citations

Lamb DC, Kelly D, Kelly S. Molecular aspects of azole antifungal action and resistance. Drug Resistance Updates. 1999. 2(6), 390-402.

  • 92 citations

Kelly SL, Arnoldi A, Kelly DE. Molecular genetic analysis of azole antifungal mode of action. Biochemical Society Transactions. 1993. 21(4), 1034-1038.

  • 88 citations

Podust LM, Kim Y, Arase M, Neely BA, Beck BJ, Bach H, Sherman DH, Lamb DC, Kelly SL, Waterman MR. The 1.92-Å structure of Streptomyces coelicolor A3(2) CYP154C1: a new monooxygenase that functionalizes macrolide ring systems. Journal of Biological Chemistry. 2003. 278(14), 12214-12221.

  • 86 citations

Lamb DC, Kelly DE, Manning NJ, Kaderbhai MA, Kelly SL. Biodiversity of the P450 catalytic cycle: yeast cytochrome b5/NADH cytochrome b5 reductase complex efficiently drives the entire sterol 14-demethylation (CYP51) reaction. FEBS Letters. 1999. 462(3), 283-288.

  • 86 citations

Martel CM, Parker JE, Bader O, Weig M, Gross U, Warrilow AGS, Kelly DE, Kelly SL. A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B. Antimicrobial Agents and Chemotherapy. 2010. 54(9), 3578-3583.

  • 83 citations

*Updated 07/11/18*