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Highly Cited Papers

Giaever G, Chu AM, Ni L, Connelly C, Riles L, Véronneau S, Dow S, Lucau-Danila A, Anderson K, André B, Arkin AP, Astromoff A, El Bakkoury M, Bangham R, Benito R, Brachat S, Campanaro S, Curtiss M, Davis K, Deutschbauer, Entian K-D, Flaherty P, Foury F, Garfinkel DJ, Gerstein M, Gotte D, Güldener U, Hegemann JH, Hempel S, Herman Z, Jaramillo DF, Kelly DE, Kelly SL, Kötter P, LaBonte D, Lamb DC, Lan N, Liang H, Liao H, Liu L, Luo C, Lussier M, Mao R, Menard P, Ooi SL, Revuelta JL, Roberts CJ, Rose M, Ross-Macdonald P, Scherens B, Schimmack G, Shafer B, Shoemaker DD, Sookhai-Mahadeo S, Storms RK, Strathern JN, Valle G, Voet M, Volckaert G, Wang C-Y, Ward TR, Wilhelmy J, Winzeler EA, Yang Y, Yen G, Youngman E, Yu K, Bussey H, Boeke JD, Snyder M, Philippsen P, Davis RW, Johnston M. Functional profiling of the Saccharomyces cerevisiae genome. Nature. 2002, 418(6896), 387-391.

  • 3518 citations
  • The UK laboratory in the transatlantic yeast gene deletion project


Denning DW, Venkareswarlu K, Oakley KL, Anderson MJ, Manning NJ, Kelly SL. Itraconazole resistance in Aspergillus fumigatus. Antimicrobial Agents and Chemotherapy. 1997, 41(6), 1364-1368.

  • 444 citations


Lupetti A, Danesi R, Campa M, Del Tacca, M, Kelly S. Molecular basis of resistance to azole antifungals, Trends in Molecular Medicine. 2002, 8(2), 76-81.

  • 393 citations


Franz R, Kelly SL, Lamb DC, Kelly DE, Ruhnke M, Morschhäuser. Multiple molecular mechanisms contribute to a stepwise development of fluconazole resistance in clinical Candida albicans. Antimicrobial Agents and Chemotherapy. 1998, 42(12), 3065-3072.

  • 327 citations


Kelly SL, Lamb DC, Kelly DE, Manning NJ, Loeffler J, Hebart H, Schumaker U, Einsele H. Resistance to fluconazole and cross resistance to amphotericin B in Candida albicans from AIDS patients caused by defective delta 5,6-desaturation. FEBS Letters. 1997, 400(1), 80-82.

  • 299 citations


Kelly SLLamb DC, Corran AJ, Baldwin BC, Kelly DE. Mode of action and resistance to azole antifungals associated with the formation of 14 alpha-methylergosta-8,24(28)-dien-3 beta, 6 alpha-diol. Biochemical and Biophysical Research Communications. 1995, 207(3), 910-915.

  • 210 citations


Lamb DC, Kelly DE, Schunck WH, Shyadehi AZ, Akhtar M, Lowe DJ, Baldwin BC, Kelly SL. The mutation T315A in Candida albicans sterol 14 alpha-demethylase causes reduced enzyme activity and fluconazole resistance through reduced affinity. Journal of Biological Chemistry. 1997, 272(9), 5682-5688.

  • 208 citations


Watson PF, Rose ME, Ellis SW, England H, Kelly SL. Defective sterol C5,6 desaturation and azole resistance: a new hypothesis for the mode of action of azole antifungals. Biochemical and Biophysical Research Communications. 1989, 164(3), 1170-1175.

  • 171 citations


Löffler J, Kelly SL, Hebart H, Schumacher U, Lass-Flörl C, Einsele H. Molecular analysis of cyp51 from fluconazole resistant Candida albicans strains. FEMS Microbiology Letters. 1997, 151(2), 263-268.

  • 159 citations


Kelly SL, Lamb DC, Kelly DE, Loeffler J, Einsele H. Resistance to fluconazole and amphotericin in Candida albicans from AIDS patients. The Lancet. 1996, 348(9040), 1523-1524.

  • 152 citations


Daum G, Tuller G, Nemec T, Hrastnik C, Balliano G, Cattel L, Milla P, Rocco F, Conzelmann A, Vionnet C, Kelly DE, Kelly S, Schweizer E, Schüller HJ, Hojad U, Greiner E, Finger K. Systematic analysis of yeast strains with possible defects in lipid metabolism. Yeast. 1999, 15(7), 601-614.

  • 142 citations


Lamb DCKelly DE, White TC, Kelly SL. The R467K amino acid substitution in Candida albicans sterol 14 alpha-demethylase causes drug resistance through reduced affinity. Antimicrobial Agents and Chemotherapy. 2000, 44(1), 63-67.

  • 131 citations


Zhao B, Guengerich FP, Bellamine, A, Lamb DC, Izumikawa M, Lei L, Podust LM, Sundaramoorthy M, Kalaitzis JA, Reddy LM, Kelly SL, Moore BS, Stec D, Voehler M, Falck JR, Shimada T, Waterman MR. Binding of two flaviolin substrate molecules, oxidative coupling, and crystal structure of Streptomyces coelicolor A3(2) cytochrome P450 158A2. Journal of Biological Chemistry. 2005, 280(12), 11599-11607.

  • 127 citations

Shyadehi AZ, Lamb DCKelly SLKelly DE, Schunck WH, Wright JN, Corina D, Akhtar M. The mechanism of the acyl-carbon bond cleavage reaction catalyzed by recombinant sterol 14 alpha-demethylase (other names are lanosterol 14 alpha-demethylase, P-450DM and CYP51). Journal of Biological Chemistry. 1996, 271(21), 12445-12450.

  • 127 citations


Jackson CJ, Barton RC, Kelly SL, Evans EGV. Strain identification of Trichophyton rubrum by specific amplication of subrepeat elements in the ribosomal DNA nontranscribed spacer. Journal of Clinical Microbiology. 2000, 38(12), 4527-4534.

  • 124 citations


Lamb DC, Skaug T, Song HL, Jackson CJ, Podust LM, Waterman MR, Kell DB, Kelly DE, Kelly SL. The cytochrome P450 complement (CYPome) of Streptomyces coelicolor A3(2). Journal of Biological Chemistry. 2002, 277(27), 24000-24005.

  • 122 citations


Kelly SL, Lamb DC, Baldwin BC, Corran AJ, Kelly DE. Characterisation of Saccharomyces cerevisiae CYP61, sterol delta 22-desaturase, and inhibtion by azole antifungal agents. Journal of Biological Chemistry. 1997, 272(15), 9986-9988.

  • 121 citations


Zhao B, Lin X, Lei L, Lamb DCKelly SL, Waterman MR, Cane DE. Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor A3(2). Journal of Biological Chemistry. 2008, 283(13), 8183-8189. 

  • 109 citations


Kelly SL, Lamb DC, Taylor M, Corran AJ, Baldwin BC, Powderly WG. Resistance to amphotericin B associated with defective sterol Δ8→7 isomerase in a Cryptococcus neoformans strain from an AIDS patient. FEMS Microbiology Letters. 1994. 122(1-2), 39-42.

  • 108 citations


Kelly SL, Lamb DC, Kelly DE. Y132H substitution in Candida albicans sterol 14alpha-demethylase confers fluconazole resistance by preventing binding to haem. FEMS Microbiology Letters. 1999. 180, 171-175.

  • 103 citations


Akhtar MK, Kelly SL, Kaderbhai MA. Cytochrome b5 modulation of 17α hydroxylase and 17-20 lyase (CYP17) activities in steroidgenesis. Journal of Endocrinology. 1999. 180(2), 171-175.

  • 101 citations


Lamb DC, Waterman MR, Kelly SL, Guengerich FP. Cytochromes P450 and drug discovery. Current Opinion in Biotechnology. 2007. 18(6), 504-512.

  • 100 citations


Kelly SL, Lamb DC, Loeffler J, Einsele H, Kelly DE. The G464S amino acid substitution in Candida albicans sterol 14alpha-demethylase causes fluconazole resistance in clinic through reduced affinity. Biochemical and Biophysical Research Communications. 1999. 262(1), 174-179.

  • 97 citations


Martel CM, Parker JE, Bader O, Weig M, Gross U, Warrilow AGS, Rolley N, Kelly DE, Kelly SL. Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. Antimicrobial Agents and Chemotherapy. 2010. 54(11), 4527-4533.

  • 90 citations

Lamb DC, Ikeda H, Nelson DR, Ishikawa J, Skaug T, Jackson C, Omura S, Waterman MR, Kelly SL. Cytochrome P450 complement (CYPome) of the avermectin-producer Streptomyces avermitilis and comparison to that of Streptomyces coelicolor A3(2). Biochemical and Biophysical Research Communications. 2003. 307(3), 610-619.

  • 90 citations

Lamb DC, Lei L, Warrilow AG, Lepesheva GI, Mullins JG, Waterman MR, Kelly SL. The first virally encoded cytochrome P450. Journal of Virology. 2009. 83(16), 8266-8269.

  • 89 citations

Lamb DC, Kelly D, Kelly S. Molecular aspects of azole antifungal action and resistance. Drug Resistance Updates. 1999. 2(6), 390-402.

  • 89 citations

Masaphy S, Levanon D, Henis Y, Venkateswarlu K, Kelly SL. Evidence for cytochrome P-450 and P-450-mediated benzo(a)pyrene hydroxylation in the white rot fungus Phanerochaete chrysosporiumFEMs Microbiology Letters. 1996. 135(1), 51-55.

  • 89 citations

Kelly SL, Arnoldi A, Kelly DE. Molecular genetic analysis of azole antifungal mode of action. Biochemical Society Transactions. 1993. 21(4), 1034-1038.

  • 87 citations

Podust LM, Kim Y, Arase M, Neely BA, Beck BJ, Bach H, Sherman DH, Lamb DC, Kelly SL, Waterman MR. The 1.92-Å structure of Streptomyces coelicolor A3(2) CYP154C1: a new monooxygenase that functionalizes macrolide ring systems. Journal of Biological Chemistry. 2003. 278(14), 12214-12221.

  • 86 citations

Lamb DC, Kelly DE, Manning NJ, Kaderbhai MA, Kelly SL. Biodiversity of the P450 catalytic cycle: yeast cytochrome b5/NADH cytochrome b5 reductase complex efficiently drives the entire sterol 14-demethylation (CYP51) reaction. FEBS Letters. 1999. 462(3), 283-288.

  • 85 citations

Kelly SL, Kelly DE. Microbial cytochromes P450: biodiversity and biotechnology. Where do cytochromes P450 come from, what do they do and what can they do for us? Philosophical Transactions of the Royal Society B. 2013. 368(1612), 20120476.

  • 80 citations
 

*Updated 09/04/18*