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Highly Cited Papers

Giaever G, Chu AM, Ni L, Connelly C, Riles L, Véronneau S, Dow S, Lucau-Danila A, Anderson K, André B, Arkin AP, Astromoff A, El Bakkoury M, Bangham R, Benito R, Brachat S, Campanaro S, Curtiss M, Davis K, Deutschbauer, Entian K-D, Flaherty P, Foury F, Garfinkel DJ, Gerstein M, Gotte D, Güldener U, Hegemann JH, Hempel S, Herman Z, Jaramillo DF, Kelly DE, Kelly SL, Kötter P, LaBonte D, Lamb DC, Lan N, Liang H, Liao H, Liu L, Luo C, Lussier M, Mao R, Menard P, Ooi SL, Revuelta JL, Roberts CJ, Rose M, Ross-Macdonald P, Scherens B, Schimmack G, Shafer B, Shoemaker DD, Sookhai-Mahadeo S, Storms RK, Strathern JN, Valle G, Voet M, Volckaert G, Wang C-Y, Ward TR, Wilhelmy J, Winzeler EA, Yang Y, Yen G, Youngman E, Yu K, Bussey H, Boeke JD, Snyder M, Philippsen P, Davis RW, Johnston M. Functional profiling of the Saccharomyces cerevisiae genome. Nature. 2002, 418(6896), 387-391.

  • 3444 citations
  • The UK laboratory in the transatlantic yeast gene deletion project

Denning DW, Venkareswarlu K, Oakley KL, Anderson MJ, Manning NJ, Kelly SL. Itraconazole resistance in Aspergillus fumigatus. Antimicrobial Agents and Chemotherapy. 1997, 41(6), 1364-1368.

  • 428 citations

Lupetti A, Danesi R, Campa M, Del Tacca, M, Kelly S. Molecular basis of resistance to azole antifungals, Trends in Molecular Medicine. 2002, 8(2), 76-81.

  • 376 citations

Franz R, Kelly SL, Lamb DC, Kelly DE, Ruhnke M, Morschhäuser. Multiple molecular mechanisms contribute to a stepwise development of fluconazole resistance in clinical Candida albicans. Antimicrobial Agents and Chemotherapy. 1998, 42(12), 3065-3072.

  • 312 citations

Kelly SL, Lamb DC, Kelly DE, Manning NJ, Loeffler J, Hebart H, Schumaker U, Einsele H. Resistance to fluconazole and cross resistance to amphotericin B in Candida albicans from AIDS patients caused by defective delta 5,6-desaturation. FEBS Letters. 1997, 400(1), 80-82.

  • 288 citations

Kelly SLLamb DC, Corran AJ, Baldwin BC, Kelly DE. Mode of action and resistance to azole antifungals associated with the formation of 14 alpha-methylergosta-8,24(28)-dien-3 beta, 6 alpha-diol. Biochemical and Biophysical Research Communications. 1995, 207(3), 910-915.

  • 207 citations

Lamb DC, Kelly DE, Schunck WH, Shyadehi AZ, Akhtar M, Lowe DJ, Baldwin BC, Kelly SL. The mutation T315A in Candida albicans sterol 14 alpha-demethylase causes reduced enzyme activity and fluconazole resistance through reduced affinity. Journal of Biological Chemistry. 1997, 272(9), 5682-5688.

  • 205 citations

Watson PF, Rose ME, Ellis SW, England H, Kelly SL. Defective sterol C5,6 desaturation and azole resistance: a new hypothesis for the mode of action of azole antifungals. Biochemical and Biophysical Research Communications. 1989, 164(3), 1170-1175.

  • 171 citations

Löffler J, Kelly SL, Hebart H, Schumacher U, Lass-Flörl C, Einsele H. Molecular analysis of cyp51 from fluconazole resistant Candida albicans strains. FEMS Microbiology Letters. 1997, 151(2), 263-268.

  • 154 citations

Kelly SL, Lamb DC, Kelly DE, Loeffler J, Einsele H. Resistance to fluconazole and amphotericin in Candida albicans from AIDS patients. The Lancet. 1996, 348(9040), 1523-1524.

  • 149 citations

Daum G, Tuller G, Nemec T, Hrastnik C, Balliano G, Cattel L, Milla P, Rocco F, Conzelmann A, Vionnet C, Kelly DE, Kelly S, Schweizer E, Schüller HJ, Hojad U, Greiner E, Finger K. Systematic analysis of yeast strains with possible defects in lipid metabolism. Yeast. 1999, 15(7), 601-614.

  • 140 citations

Lamb DCKelly DE, White TC, Kelly SL. The R467K amino acid substitution in Candida albicans sterol 14 alpha-demethylase causes drug resistance through reduced affinity. Antimicrobial Agents and Chemotherapy. 2000, 44(1), 63-67.

  • 128 citations

Zhao B, Guengerich FP, Bellamine, A, Lamb DC, Izumikawa M, Lei L, Podust LM, Sundaramoorthy M, Kalaitzis JA, Reddy LM, Kelly SL, Moore BS, Stec D, Voehler M, Falck JR, Shimada T, Waterman MR. Binding of two flaviolin substrate molecules, oxidative coupling, and crystal structure of Streptomyces coelicolor A3(2) cytochrome P450 158A2. Journal of Biological Chemistry. 2005, 280(12), 11599-11607.

  • 122 citations

Lamb DC, Skaug T, Song HL, Jackson CJ, Podust LM, Waterman MR, Kell DB, Kelly DE, Kelly SL. The cytochrome P450 complement (CYPome) of Streptomyces coelicolor A3(2). Journal of Biological Chemistry. 2002, 277(27), 24000-24005.

  • 122 citations

Shyadehi AZ, Lamb DCKelly SLKelly DE, Schunck WH, Wright JN, Corina D, Akhtar M. The mechanism of the acyl-carbon bond cleavage reaction catalyzed by recombinant sterol 14 alpha-demethylase (other names are lanosterol 14 alpha-demethylase, P-450DM and CYP51). Journal of Biological Chemistry. 1996, 271(21), 12445-12450.

  • 122 citations

Jackson CJ, Barton RC, Kelly SL, Evans EGV. Strain identification of Trichophyton rubrum by specific amplication of subrepeat elements in the ribosomal DNA nontranscribed spacer. Journal of Clinical Microbiology. 2000, 38(12), 4527-4534.

  • 120 citations

Kelly SL, Lamb DC, Baldwin BC, Corran AJ, Kelly DE. Characterisation of Saccharomyces cerevisiae CYP61, sterol delta 22-desaturase, and inhibtion by azole antifungal agents. Journal of Biological Chemistry. 1997, 272(15), 9986-9988.

  • 119 citations

Kelly SL, Lamb DC, Taylor M, Corran AJ, Baldwin BC, Powderly WG. Resistance to amphotericin B associated with defective sterol Δ8→7 isomerase in a Cryptococcus neoformans strain from an AIDS patient. FEMS Microbiology Letters. 1994. 122(1-2), 39-42.

  • 106 citations

Zhao B, Lin X, Lei L, Lamb DCKelly SL, Waterman MR, Cane DE. Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor A3(2). Journal of Biological Chemistry. 2008, 283(13), 8183-8189. 

  • 100 citations

Akhtar MK, Kelly SL, Kaderbhai MA. Cytochrome b5 modulation of 17α hydroxylase and 17-20 lyase (CYP17) activities in steroidgenesis. Journal of Endocrinology. 1999. 180(2), 171-175.

  • 98 citations

Kelly SL, Lamb DC, Kelly DE. Y132H substitution in Candida albicans sterol 14alpha-demethylase confers fluconazole resistance by preventing binding to haem. FEMS Microbiology Letters. 1999. 180, 171-175.

  • 97 citations

*Updated 21/11/17*