Highly Cited Papers

Giaever G, Chu AM, Ni L, Connelly C, Riles L, Véronneau S, Dow S, Lucau-Danila A, Anderson K, André B, Arkin AP, Astromoff A, El Bakkoury M, Bangham R, Benito R, Brachat S, Campanaro S, Curtiss M, Davis K, Deutschbauer, Entian K-D, Flaherty P, Foury F, Garfinkel DJ, Gerstein M, Gotte D, Güldener U, Hegemann JH, Hempel S, Herman Z, Jaramillo DF, Kelly DE, Kelly SL, Kötter P, LaBonte D, Lamb DC, Lan N, Liang H, Liao H, Liu L, Luo C, Lussier M, Mao R, Menard P, Ooi SL, Revuelta JL, Roberts CJ, Rose M, Ross-Macdonald P, Scherens B, Schimmack G, Shafer B, Shoemaker DD, Sookhai-Mahadeo S, Storms RK, Strathern JN, Valle G, Voet M, Volckaert G, Wang C-Y, Ward TR, Wilhelmy J, Winzeler EA, Yang Y, Yen G, Youngman E, Yu K, Bussey H, Boeke JD, Snyder M, Philippsen P, Davis RW, Johnston M. Functional profiling of the Saccharomyces cerevisiae genome. Nature. 2002, 418(6896), 387-391.

  • 4253 citations

  • The UK laboratory in the transatlantic yeast gene deletion project

Denning DW, Venkateswarlu K, Oakley KL, Anderson MJ, Manning NJ, Kelly SL. Itraconazole resistance in Aspergillus fumigatus. Antimicrobial Agents and Chemotherapy. 1997, 41(6), 1364-1368.

  • 528 citations

Lupetti A, Danesi R, Campa M, Del Tacca, M, Kelly S. Molecular basis of resistance to azole antifungals, Trends in Molecular Medicine. 2002, 8(2), 76-81.

  • 482 citations

Franz R, Kelly SL, Lamb DC, Kelly DE, Ruhnke M, Morschhäuser J. Multiple molecular mechanisms contribute to a stepwise development of fluconazole resistance in clinical Candida albicans. Antimicrobial Agents and Chemotherapy. 1998, 42(12), 3065-3072.

  • 380 citations

Kelly SL, Lamb DC, Kelly DE, Manning NJ, Loeffler J, Hebart H, Schumaker U, Einsele H. Resistance to fluconazole and cross resistance to amphotericin B in Candida albicans from AIDS patients caused by defective sterol delta 5,6-desaturation. FEBS Letters. 1997, 400(1), 80-82.

  • 365 citations

Kelly SL, Lamb DC, Corran AJ, Baldwin BC, Kelly DE. Mode of action and resistance to azole antifungals associated with the formation of 14 alpha-methylergosta-8,24(28)-dien-3 beta, 6 alpha-diol. Biochemical and Biophysical Research Communications. 1995, 207(3), 910-915.

  • 265 citations

Lamb DC, Kelly DE, Schunck WH, Shyadehi AZ, Akhtar M, Lowe DJ, Baldwin BC, Kelly SL. The mutation T315A in Candida albicans sterol 14 alpha-demethylase causes reduced enzyme activity and fluconazole resistance through reduced affinity. Journal of Biological Chemistry. 1997, 272(9), 5682-5688.

  • 229 citations

Watson PF, Rose ME, Ellis SW, England H, Kelly SL. Defective sterol C5,6 desaturation and azole resistance: a new hypothesis for the mode of action of azole antifungals. Biochemical and Biophysical Research Communications. 1989, 164(3), 1170-1175.

  • 187 citations

Löffler J, Kelly SL, Hebart H, Schumacher U, Lass-Flörl C, Einsele H. Molecular analysis of cyp51 from fluconazole resistant Candida albicans strains. FEMS Microbiology Letters. 1997, 151(2), 263-268.

  • 184 citations

Daum G, Tuller G, Nemec T, Hrastnik C, Balliano G, Cattel L, Milla P, Rocco F, Conzelmann A, Vionnet C, Kelly DE, Kelly S, Schweizer E, Schüller HJ, Hojad U, Greiner E, Finger K. Systematic analysis of yeast strains with possible defects in lipid metabolism. Yeast. 1999, 15(7), 601-614.

  • 165 citations

Lamb DC, Kelly DE, White TC, Kelly SL. The R467K amino acid substitution in Candida albicans sterol 14 alpha-demethylase causes drug resistance through reduced affinity. Antimicrobial Agents and Chemotherapy. 2000, 44(1), 63-67.

  • 155 citations

Kelly SL, Lamb DC, Kelly DE, Loeffler J, Einsele H. Resistance to fluconazole and amphotericin in Candida albicans from AIDS patients. The Lancet. 1996, 348(9040), 1523-1524.

  • 153 citations

Lamb DC, Skaug T, Song HL, Jackson CJ, Podust LM, Waterman MR, Kell DB, Kelly DE, Kelly SL. The cytochrome P450 complement (CYPome) of Streptomyces coelicolor A3(2). Journal of Biological Chemistry. 2002, 277(27), 24000-24005.

  • 150 citations

Lamb DC, Lei L, Warrilow AG, Lepesheva GI, Mullins JG, Waterman MR, Kelly SL. The first virally encoded cytochrome P450. Journal of Virology. 2009. 83(16), 8266-8269.

  • 149 citations

Zhao B, Guengerich FP, Bellamine, A, Lamb DC, Izumikawa M, Lei L, Podust LM, Sundaramoorthy M, Kalaitzis JA, Reddy LM, Kelly SL, Moore BS, Stec D, Voehler M, Falck JR, Shimada T, Waterman MR. Binding of two flaviolin substrate molecules, oxidative coupling, and crystal structure of Streptomyces coelicolor A3(2) cytochrome P450 158A2. Journal of Biological Chemistry. 2005, 280(12), 11599-11607.

  • 145 citations

Kelly SL, Kelly DE. Microbial cytochromes P450: biodiversity and biotechnology. Where do cytochromes P450 come from, what do they do and what can they do for us? Phil Trans R Soc B. 2013. 368(1612), 20120476.

  • 145 citations

Kelly SL, Lamb DC, Baldwin BC, Corran AJ, Kelly DE. Characterisation of Saccharomyces cerevisiae CYP61, sterol delta 22-desaturase, and inhibtion by azole antifungal agents. Journal of Biological Chemistry. 1997, 272(15), 9986-9988.

  • 144 citations

Zhao B, Lin X, Lei L, Lamb DC, Kelly SL, Waterman MR, Cane DE. Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor A3(2). Journal of Biological Chemistry. 2008, 283(13), 8183-8189.

  • 142 citations

Jackson CJ, Barton RC, Kelly SL, Evans EGV. Strain identification of Trichophyton rubrum by specific amplication of subrepeat elements in the ribosomal DNA nontranscribed spacer. Journal of Clinical Microbiology. 2000, 38(12), 4527-4534.

  • 142 citations

Shyadehi AZ, Lamb DC, Kelly SL, Kelly DE, Schunck WH, Wright JN, Corina D, Akhtar M. The mechanism of the acyl-carbon bond cleavage reaction catalyzed by recombinant sterol 14 alpha-demethylase (other names are lanosterol 14 alpha-demethylase, P-450DM and CYP51). Journal of Biological Chemistry. 1996, 271(21), 12445-12450.

  • 142 citations

Martel CM, Parker JE, Bader O, Weig M, Gross U, Warrilow AGS, Rolley N, Kelly DE, Kelly SL. Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. Antimicrobial Agents and Chemotherapy. 2010. 54(11), 4527-4533.

  • 137 citations

Price CL, Parker JE, Warrilow AGS, Kelly DE, Kelly SL. Azole fungicides - understanding resistance mechanisms in agricultural fungal pathogens. Pest Management Science. 2015, 71(8), 1054-1058.

  • 133 citations

Lamb DC, Waterman MR, Kelly SL, Guengerich FP. Cytochromes P450 and drug discovery. Current Opinion in Biotechnology. 2007. 18(6), 504-512.

  • 122 citations

Kelly SL, Lamb DC, Taylor M, Corran AJ, Baldwin BC, Powderly WG. Resistance to amphotericin B associated with defective sterol Δ8→7 isomerase in a Cryptococcus neoformans strain from an AIDS patient. FEMS Microbiology Letters. 1994. 122(1-2), 39-42.

  • 121 citations

Martel CM, Parker JE, Bader O, Weig M, Gross U, Warrilow AGS, Kelly DE, Kelly SL. A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B. Antimicrobial Agents and Chemotherapy. 2010. 54(9), 3578-3583.

  • 120 citations

Kelly SL, Lamb DC, Loeffler J, Einsele H, Kelly DE. The G464S amino acid substitution in Candida albicans sterol 14alpha-demethylase causes fluconazole resistance in clinic through reduced affinity. Biochemical and Biophysical Research Communications. 1999. 262(1), 174-179.

  • 118 citations

Akhtar MK, Kelly SL, Kaderbhai MA. Cytochrome b5 modulation of 17α hydroxylase and 17-20 lyase (CYP17) activities in steroidgenesis. Journal of Endocrinology. 1999. 180(2), 171-175.

  • 117 citations

Kelly SL, Lamb DC, Kelly DE. Y132H substitution in Candida albicans sterol 14alpha-demethylase confers fluconazole resistance by preventing binding to haem. FEMS Microbiology Letters. 1999. 180, 171-175.

  • 117 citations

Eddouzi J, Parker JE, Vale-Silva LA, Coste A, Ischer F, Kelly S, Manai M, Sanglard D. Molecular mechanisms of drug resistance in clinical Candida species isolated from Tunisian hospitals. Antimicrobial Agents and Chemotherapy. 2013, 57(7), 3182-3193.

  • 111 citations

Lamb DC, Ikeda H, Nelson DR, Ishikawa J, Skaug T, Jackson C, Omura S, Waterman MR, Kelly SL. Cytochrome P450 complement (CYPome) of the avermectin-producer Streptomyces avermitilis and comparison to that of Streptomyces coelicolor A3(2). Biochemical and Biophysical Research Communications. 2003. 307(3), 610-619.

  • 108 citations

Wortman JR, Gilsenan JM, Joardar V, Deegan J, Clutterbuck J, Andersen MR, Archer D, Bencina M, Braus G, Coutinho P, von Döhren H, Doonan J, Driessen AJM, Durek P, Espeso E, Fekete E, Flipphi M, Estrada CG, Geysens S, Goldman G, de Groot PWJ, Hansen K, Harris SD, Heinekamp T, Helmstaedt K, Henrissat B, Hofmann G, HomanT, Horio T, Horiuchi H, James S, Jones M, Karaffa L, Karányiad Z, Kato M, Keller N, Kelly DE, Kiel JAKW, Kim J, van der Klei IJ, Klis FM, Kovalchuk A, Kraševec N, Kubicek CP, Liu B, MacCabe A, Meyer V, Mirabito P, Miskei M, Mos M, Mullins J, Nelson DR, Nielsen J, Oakley BR, Osmani SA, Pakula T, Paszewski A, Paulsen I, Pilsyk S, Pócsi I, Punt PJ, Ram AFJ, RenQ, Robellet X, Robson G, Seiboth B, van Solingen P, Specht T, Sun J, Taheri-Talesh N, Takeshita N, Ussery D, vanKuyk PA, Visser H, van de Vondervoort PJI, de Vries RP, Walton J, Xiang X, Xiong Y, Zeng AP, Brandt BW, Cornell MJ, van den Hondel CAMJJ, Visser J, Oliver SG, Turner T. The 2008 update of the Aspergillus nidulans genome annotation: A community effort. Fungal Genetics and Biology. 2009, 46(1), suppl. 1, S2- S13.

  • 104 citations

Warrilow AG, Parker JE, Kelly DE, Kelly SL. Azole affinity of sterol 14 alpha-demethylase (CYP51) enzymes from Candida albicans and Homo sapiens. Antimicrobial Agents and Chemotherapy. 2013, 57(3), 1352-1360.

  • 104 citations

Fan JR, Urban M, Parker JE, Brewer HC, Kelly SL, Hammond-Kosack KE, Fraaije BA, Liu XL, Cools HJ. Characterization of the sterol 14 alpha-demethylases of Fusarium graminearum identifies a novel genus-specific CYP51 function. New Phytologist. 2013, 198(3), 821-835.

  • 102 citations

Cools HJ, Parker JE, Kelly DE, Lucas JA, Fraaije BA, Kelly SL. Heterologous expression of mutated eburicol 14 alpha-demethylase (CYP51) proteins of Mycosphaerella graminicola to assess effects on azole fungicide Sensitivity and intrinsic protein function. Applied and Environmental Microbiology. 2010, 76(9), 2866-2872.

  • 101 citations

Lamb DC, Kelly D, Kelly S. Molecular aspects of azole antifungal action and resistance. Drug Resistance Updates. 1999. 2(6), 390-402.

  • 100 citations

Kelly SL, Arnoldi A, Kelly DE. Molecular genetic analysis of azole antifungal mode of action. Biochemical Society Transactions. 1993. 21(4), 1034-1038.

  • 99 citations

Masaphy S, Levanon D, Henis Y, Venkateswarlu K, Kelly SL. Evidence for cytochrome P-450 and P-450-mediated benzo(a)pyrene hydroxylation in the white rot fungus Phanerochaete chrysosporium. FEMs Microbiology Letters. 1996. 135(1), 51-55.

  • 95 citations

Parker JE, Warrilow AGS, Price CL, Mullins JGL, Kelly DE, Kelly SL. Resistance to antifungals that target CYP51. Journal of Chemical Biology. 2014, 7(4), 143-161.

  • 95 citations

Podust LM, Kim Y, Arase M, Neely BA, Beck BJ, Bach H, Sherman DH, Lamb DC, Kelly SL, Waterman MR. The 1.92-Å structure of Streptomyces coelicolor A3(2) CYP154C1: a new monooxygenase that functionalizes macrolide ring systems. Journal of Biological Chemistry. 2003. 278(14), 12214-12221.

  • 94 citations

Warrilow AGS, Martel CM, Parker JE, Melo N, Lamb DC, Nes D, Kelly DE, Kelly SL. Azole binding properties of Candida albicans sterol 14-alpha demethylase (CaCYP51). Antimicrobial Agents and Chemotherapy. 2010, 54(10), 4235-4245.

  • 94 citations

Chun Y-J, Shimada T, Sanchez-Ponce R, Martin MV, Lei L, Zhao B, Kelly SL, Waterman MR, Lamb DC, Guengerich FP. Electron Transport Pathway for a Streptomyces P450. Journal of Biological Chemistry. 2007. 282(24), 17486-17500.

  • 92 citations

Lamb DC, Kelly DE, Manning NJ, Kaderbhai MA, Kelly SL. Biodiversity of the P450 catalytic cycle: yeast cytochrome b5/NADH cytochrome b5 reductase complex efficiently drives the entire sterol 14-demethylation (CYP51) reaction. FEBS Letters. 1999. 462(3), 283-288.

  • 91 citations



*Updated 08/12/20*