Highly Cited Papers

Giaever G, Chu AM, Ni L, Connelly C, Riles L, Véronneau S, Dow S, Lucau-Danila A, Anderson K, André B, Arkin AP, Astromoff A, El Bakkoury M, Bangham R, Benito R, Brachat S, Campanaro S, Curtiss M, Davis K, Deutschbauer, Entian K-D, Flaherty P, Foury F, Garfinkel DJ, Gerstein M, Gotte D, Güldener U, Hegemann JH, Hempel S, Herman Z, Jaramillo DF, Kelly DE, Kelly SL, Kötter P, LaBonte D, Lamb DC, Lan N, Liang H, Liao H, Liu L, Luo C, Lussier M, Mao R, Menard P, Ooi SL, Revuelta JL, Roberts CJ, Rose M, Ross-Macdonald P, Scherens B, Schimmack G, Shafer B, Shoemaker DD, Sookhai-Mahadeo S, Storms RK, Strathern JN, Valle G, Voet M, Volckaert G, Wang C-Y, Ward TR, Wilhelmy J, Winzeler EA, Yang Y, Yen G, Youngman E, Yu K, Bussey H, Boeke JD, Snyder M, Philippsen P, Davis RW, Johnston M. Functional profiling of the Saccharomyces cerevisiae genome. Nature. 2002, 418(6896), 387-391.

  • 3914 citations
  • The UK laboratory in the transatlantic yeast gene deletion project

Denning DW, Venkareswarlu K, Oakley KL, Anderson MJ, Manning NJ, Kelly SL. Itraconazole resistance in Aspergillus fumigatus. Antimicrobial Agents and Chemotherapy. 1997, 41(6), 1364-1368.

  • 495 citations

Lupetti A, Danesi R, Campa M, Del Tacca, M, Kelly S. Molecular basis of resistance to azole antifungals, Trends in Molecular Medicine. 2002, 8(2), 76-81.

  • 439 citations

Franz R, Kelly SL, Lamb DC, Kelly DE, Ruhnke M, Morschhäuser J. Multiple molecular mechanisms contribute to a stepwise development of fluconazole resistance in clinical Candida albicans. Antimicrobial Agents and Chemotherapy. 1998, 42(12), 3065-3072.

  • 362 citations

Kelly SL, Lamb DC, Kelly DE, Manning NJ, Loeffler J, Hebart H, Schumaker U, Einsele H. Resistance to fluconazole and cross resistance to amphotericin B in Candida albicans from AIDS patients caused by defective sterol delta 5,6-desaturation. FEBS Letters. 1997, 400(1), 80-82.

  • 331 citations

Kelly SL, Lamb DC, Corran AJ, Baldwin BC, Kelly DE. Mode of action and resistance to azole antifungals associated with the formation of 14 alpha-methylergosta-8,24(28)-dien-3 beta, 6 alpha-diol. Biochemical and Biophysical Research Communications. 1995, 207(3), 910-915.

  • 241 citations

Lamb DC, Kelly DE, Schunck WH, Shyadehi AZ, Akhtar M, Lowe DJ, Baldwin BC, Kelly SL. The mutation T315A in Candida albicans sterol 14 alpha-demethylase causes reduced enzyme activity and fluconazole resistance through reduced affinity. Journal of Biological Chemistry. 1997, 272(9), 5682-5688.

  • 223 citations

Watson PF, Rose ME, Ellis SW, England H, Kelly SL. Defective sterol C5,6 desaturation and azole resistance: a new hypothesis for the mode of action of azole antifungals. Biochemical and Biophysical Research Communications. 1989, 164(3), 1170-1175.

  • 184 citations

Löffler J, Kelly SL, Hebart H, Schumacher U, Lass-Flörl C, Einsele H. Molecular analysis of cyp51 from fluconazole resistant Candida albicans strains. FEMS Microbiology Letters. 1997, 151(2), 263-268.

  • 174 citations

Daum G, Tuller G, Nemec T, Hrastnik C, Balliano G, Cattel L, Milla P, Rocco F, Conzelmann A, Vionnet C, Kelly DE, Kelly S, Schweizer E, Schüller HJ, Hojad U, Greiner E, Finger K. Systematic analysis of yeast strains with possible defects in lipid metabolism. Yeast. 1999, 15(7), 601-614.

  • 152 citations

Lamb DC, Kelly DE, White TC, Kelly SL. The R467K amino acid substitution in Candida albicans sterol 14 alpha-demethylase causes drug resistance through reduced affinity. Antimicrobial Agents and Chemotherapy. 2000, 44(1), 63-67.

  • 150 citations

Kelly SL, Lamb DC, Kelly DE, Loeffler J, Einsele H. Resistance to fluconazole and amphotericin in Candida albicans from AIDS patients. The Lancet. 1996, 348(9040), 1523-1524.

  • 149 citations

Lamb DC, Skaug T, Song HL, Jackson CJ, Podust LM, Waterman MR, Kell DB, Kelly DE, Kelly SL. The cytochrome P450 complement (CYPome) of Streptomyces coelicolor A3(2). Journal of Biological Chemistry. 2002, 277(27), 24000-24005.

  • 144 citations

Zhao B, Guengerich FP, Bellamine, A, Lamb DC, Izumikawa M, Lei L, Podust LM, Sundaramoorthy M, Kalaitzis JA, Reddy LM, Kelly SL, Moore BS, Stec D, Voehler M, Falck JR, Shimada T, Waterman MR. Binding of two flaviolin substrate molecules, oxidative coupling, and crystal structure of Streptomyces coelicolor A3(2) cytochrome P450 158A2. Journal of Biological Chemistry. 2005, 280(12), 11599-11607.

  • 138 citations

Shyadehi AZ, Lamb DC, Kelly SL, Kelly DE, Schunck WH, Wright JN, Corina D, Akhtar M. The mechanism of the acyl-carbon bond cleavage reaction catalyzed by recombinant sterol 14 alpha-demethylase (other names are lanosterol 14 alpha-demethylase, P-450DM and CYP51). Journal of Biological Chemistry. 1996, 271(21), 12445-12450.

  • 136 citations

Jackson CJ, Barton RC, Kelly SL, Evans EGV. Strain identification of Trichophyton rubrum by specific amplication of subrepeat elements in the ribosomal DNA nontranscribed spacer. Journal of Clinical Microbiology. 2000, 38(12), 4527-4534.

  • 134 citations

Kelly SL, Lamb DC, Baldwin BC, Corran AJ, Kelly DE. Characterisation of Saccharomyces cerevisiae CYP61, sterol delta 22-desaturase, and inhibtion by azole antifungal agents. Journal of Biological Chemistry. 1997, 272(15), 9986-9988.

  • 132 citations

Zhao B, Lin X, Lei L, Lamb DC, Kelly SL, Waterman MR, Cane DE. Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor A3(2). Journal of Biological Chemistry. 2008, 283(13), 8183-8189.

  • 127 citations

Kelly SL, Kelly DE. Microbial cytochromes P450: biodiversity and biotechnology. Where do cytochromes P450 come from, what do they do and what can they do for us? Phil Trans R Soc B. 2013. 368(1612), 20120476.

  • 126 citations

Martel CM, Parker JE, Bader O, Weig M, Gross U, Warrilow AGS, Rolley N, Kelly DE, Kelly SL. Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. Antimicrobial Agents and Chemotherapy. 2010. 54(11), 4527-4533.

  • 123 citations

Kelly SL, Lamb DC, Kelly DE. Y132H substitution in Candida albicans sterol 14alpha-demethylase confers fluconazole resistance by preventing binding to haem. FEMS Microbiology Letters. 1999. 180, 171-175.

  • 116 citations

Kelly SL, Lamb DC, Taylor M, Corran AJ, Baldwin BC, Powderly WG. Resistance to amphotericin B associated with defective sterol Δ8→7 isomerase in a Cryptococcus neoformans strain from an AIDS patient. FEMS Microbiology Letters. 1994. 122(1-2), 39-42.

  • 114 citations

Lamb DC, Lei L, Warrilow AG, Lepesheva GI, Mullins JG, Waterman MR, Kelly SL. The first virally encoded cytochrome P450. Journal of Virology. 2009. 83(16), 8266-8269.

  • 114 citations

Akhtar MK, Kelly SL, Kaderbhai MA. Cytochrome b5 modulation of 17α hydroxylase and 17-20 lyase (CYP17) activities in steroidgenesis. Journal of Endocrinology. 1999. 180(2), 171-175.

  • 113 citations

Kelly SL, Lamb DC, Loeffler J, Einsele H, Kelly DE. The G464S amino acid substitution in Candida albicans sterol 14alpha-demethylase causes fluconazole resistance in clinic through reduced affinity. Biochemical and Biophysical Research Communications. 1999. 262(1), 174-179.

  • 111 citations

Lamb DC, Waterman MR, Kelly SL, Guengerich FP. Cytochromes P450 and drug discovery. Current Opinion in Biotechnology. 2007. 18(6), 504-512.

  • 107 citations

Martel CM, Parker JE, Bader O, Weig M, Gross U, Warrilow AGS, Kelly DE, Kelly SL. A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B. Antimicrobial Agents and Chemotherapy. 2010. 54(9), 3578-3583.

  • 105 citations

Lamb DC, Ikeda H, Nelson DR, Ishikawa J, Skaug T, Jackson C, Omura S, Waterman MR, Kelly SL. Cytochrome P450 complement (CYPome) of the avermectin-producer Streptomyces avermitilis and comparison to that of Streptomyces coelicolor A3(2). Biochemical and Biophysical Research Communications. 2003. 307(3), 610-619.

  • 100 citations

Eddouzi J, Parker JE, Vale-Silva LA, Coste A, Ischer F, Kelly S, Manai M, Sanglard D. Molecular mechanisms of drug resistance in clinical Candida species isolated from Tunisian hospitals. Antimicrobial Agents and Chemotherapy. 2013, 57(7), 3182-3193.

  • 95 citations

Price CL, Parker JE, Warrilow AGS, Kelly DE, Kelly SL. Azole fungicides - understanding resistance mechanisms in agricultural fungal pathogens. Pest Management Science. 2015, 71(8), 1054-1058.

  • 94 citations

Kelly SL, Arnoldi A, Kelly DE. Molecular genetic analysis of azole antifungal mode of action. Biochemical Society Transactions. 1993. 21(4), 1034-1038.

  • 94 citations

Lamb DC, Kelly D, Kelly S. Molecular aspects of azole antifungal action and resistance. Drug Resistance Updates. 1999. 2(6), 390-402.

  • 94 citations

Masaphy S, Levanon D, Henis Y, Venkateswarlu K, Kelly SL. Evidence for cytochrome P-450 and P-450-mediated benzo(a)pyrene hydroxylation in the white rot fungus Phanerochaete chrysosporium. FEMs Microbiology Letters. 1996. 135(1), 51-55.

  • 92 citations

Podust LM, Kim Y, Arase M, Neely BA, Beck BJ, Bach H, Sherman DH, Lamb DC, Kelly SL, Waterman MR. The 1.92-Å structure of Streptomyces coelicolor A3(2) CYP154C1: a new monooxygenase that functionalizes macrolide ring systems. Journal of Biological Chemistry. 2003. 278(14), 12214-12221.

  • 90 citations

Warrilow AGS, Martel CM, Parker JE, Melo N, Lamb DC, Nes D, Kelly DE, Kelly SL. Azole binding properties of Candida albicans sterol 14-alpha demethylase (CaCYP51). Antimicrobial Agents and Chemotherapy. 2010, 54(10), 4235-4245.

  • 88 citations

Lamb DC, Kelly DE, Manning NJ, Kaderbhai MA, Kelly SL. Biodiversity of the P450 catalytic cycle: yeast cytochrome b5/NADH cytochrome b5 reductase complex efficiently drives the entire sterol 14-demethylation (CYP51) reaction. FEBS Letters. 1999. 462(3), 283-288.

  • 87 citations

Chun Y-J, Shimada T, Sanchez-Ponce R, Martin MV, Lei L, Zhao B, Kelly SL, Waterman MR, Lamb DC, Guengerich FP. Electron Transport Pathway for a Streptomyces P450. Journal of Biological Chemistry. 2007. 282(24), 17486-17500.

  • 86 citations

Cools HJ, Parker JE, Kelly DE, Lucas JA, Fraaije BA, Kelly SL. Heterologous expression of mutated eburicol 14 alpha-demethylase (CYP51) proteins of Mycosphaerella graminicola to assess effects on azole fungicide Sensitivity and intrinsic protein function. Applied and Environmental Microbiology. 2010, 76(9), 2866-2872.

  • 84 citations

Warrilow AG, Parker JE, Kelly DE, Kelly SL. Azole affinity of sterol 14 alpha-demethylase (CYP51) enzymes from Candida albicans and Homo sapiens. Antimicrobial Agents and Chemotherapy. 2013, 57(3), 1352-1360.

  • 83 citations

Lamb DC, Kelly DE, Waterman MR, Stromstedt M, Rozman D, Kelly SL. Characteristics of the heterologously expressed human lanosterol 14α-demethylase (other names: P45014M, CYP51, P45051) and inhibition of the purified human and Candida albicans CYP51 with azole antifungal agents. Yeast. 1999, 15(9), 755-763.

  • 82 citations



*Updated 07/11/19*